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Freezing causes ice crystal formation, which physically disrupts amino acid structure and denatures dissolved compounds

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Such disruptions have been associated with worsened DED symptoms, decreased corneal barrier function, and reduced epithelial cell density, indicating a negative correlation between microbial diversity and DED severity (Mendez et al., 2020)

A commenter stated that the measure has not been tested with a self-administration option and recommended testing self-administration and resolving barriers prior to adopting this measure

This is a precautionary recommendation, not a declaration that oral birth control fails entirely

"It's going great," Martin said