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Initiation of therapy typically involves a low starting dose to reduce gastrointestinal side effects, followed by gradual titration based on clinical response and tolerability

These target the GLP-1 receptor, which, in simple terms, makes you less hungry

Given their dual benefits in obesity and inflammation regulation, GLP-1RAs medications hold potential as disease-modifying therapies for OA

However, the interaction between these medications requires thoughtful consideration due to semaglutide's effect on gastrointestinal motility

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Together, they can reduce the sharp highs and lows that make energy feel unstable