An alternative are anti-diabetic agents such as the GLP-1 mimetics which have been developed to normalise insulin signalling in diabetic patients with great success
Ryder SD, Beckingham IJ (2001)
The Energy Content and Composition of Meals Consumed after an Overnight Fast and Their Effects on Diet Induced Thermogenesis: A Systematic Review, Meta-Analyses and Meta-Regressions
GLP-1 Medications Work Strongest After Injection GLP-1s are designed to slow digestion, curb cravings, and reduce appetite and those effects are most noticeable in the 12 days following your shot
In the periphery, as an instant progression from the central disturbance, a multiorgan failure syndrome appeared, comparable to the deadly syndromes induced by the peripheral vessels occlusion, the suprahepatic occlusion of the inferior caval vein (BuddChiari syndrome) or Pringle maneuver ischemia, reperfusion (i.e., heart, lung, liver, kidney, gastrointestinal lesions and thrombosis progression) [26,27]
Based on the experience of the observer, the specific morphological features of the cytoplasmic vacuolation may be sufficiently consistent with intracytoplasmic lipid accumulation to warrant a presumptive diagnosis of fatty change