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The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis

Nature 412 , 549553 (2001)

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Long-acting GLP-1RAs have been shown to influence body weight by modulating food intake and energy expenditure through various hypothalamic pathways (45)

Fatigue may also occur

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