doi: 10.1038/nature09922 66 JaneiroMHRamrezMJMilagroFIMartnezJASolasM
Relationship of gastric emptying or accommodation with satiation, satiety, and postprandial symptoms in health
A recent study showed that a glycocalyx-mimetic nanoparticle library may facilitate drug delivery [118]
The route of delivery suggests that the peptides will be able to interact with the GLP-1 receptors on the vagal afferents of the intestine, as is the case for native GLP-1 in healthy individuals
Genome Med , 2012, 4(8): 67-77
Experience with oral GLP1 use in diabetes has highlighted this disconnect: tablets are often not viewed as premium products, and the scientific and manufacturing innovation required to enable the oral delivery of biologics can be underappreciated at times reduced to just a pill. This perception gap may pose commercial challenges, especially when oral therapies are priced alongside injectable alternatives