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Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs

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Patent protection prevents other manufacturers from producing true generic versions until patents expire

In addition to JPH-203, other drugs currently in preclinical and clinical trials targeting LAT1 include IPA-131, QBS-10072S, TLX101-CDx, 124I-ACD-101, 211At-TLX-102, OKY-034, [18F] NKO-028 (Table 1)

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It also supports the regeneration of other key antioxidants, such as Vitamin C and Vitamin E, making it a cornerstone of cellular resilience