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These compounds are thought to have a synergistic effect and are essential components necessary for many physiological systems within the body

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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

Others use abdominal or deltoid sites for systemic delivery

Zant A, Awwad HM, Geisel J, Keller M, Obeid R