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D+Q works by inhibiting pro-survival pathways (tyrosine kinases and Bcl-2 family) broadlythese pathways are also present in non-senescent cells, creating off-target effects

Astrocytes and microglia play a crucial role in regulating inflammation within the nervous system through the secretion of various cytokines and inflammatory mediators, such as IL-1, TNF-, and complement component 1q

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2002, 18(9): 782-783

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