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This makes it particularly relevant in clinical contexts where someone has gut lining compromise alongside systemic inflammation, for example, long-term NSAID use for chronic pain

The neurodegeneration is associated with decontrolled inflammatory responses into the CNS

Heres a brief overview of some common alternatives that are FDA-approved for weight loss in certain people, along with some pros and cons to consider for each one

For instance, Wu et al

Preclinical studies suggested that combining GLP-1, GIP and glucagon receptor activation could yield even greater metabolic benefits than previous therapies

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