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The randomisation number encoded the subjects assignment to one of the treatment arms according to the randomisation list generated before the trial, using block randomisation (randomisation lists were provided by PAREXEL International, Nottingham, UK)

Pattern HED extrapolation ceiling Daily Dose ~650 mg/day Tablet Math (50 mg) 13 tablets/day included only to show the gap with vendor doses Frequency n/a Notes Allometric scaling from 100 mg/kg/day mouse dose to 80 kg human