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SARM1 activation triggers axon degeneration locally via NAD+ destruction

The clinical significance of this varies depending on dose and formulation, but its not something to brush past

In contrast, when the concentration of carnitine in the plasma increases and the filtration load of carnitine increases, the kidney rapidly increases the rate of carnitine excretion and reduces its reabsorption efficiency to prevent the excessive accumulation of carnitine in the body

Strebhardt K, Ullrich A

This makes it uniquely suited for people with chronic inflammatory conditions or autoimmune disorders

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