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PMID 12446535

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The current gold-standard approach to assess metabolite interactions in such cases is isotopic labeling, which allows the tracking of one or more heavy elemental isotopes through the metabolome with mass spectrometry, nuclear-magnetic resonance, or similar metabolomic techniques (Wang et al., 2024)

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The study also revealed an unexpected pathway-dependent response: in telomerase-positive cancer cell lines, telomere elongation occurred through alternative lengthening of telomeres (ALT) activation rather than telomerase upregulation, suggesting that the AEDG sequences interaction with telomere maintenance pathways is more complex than initially characterized