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Spatial hubs for crosstalk: contacts and microdomains Organelle contact sites are active hubs where multiple reactive chemistries are choreographed rather than isolated: at mitochondriaER contacts (MAMs), tightly coupled Ca and lipid transfer is synchronized with ROS generation and detoxification, so that ONOO , H 2 O 2 and RSS can be relayed across adjacent membranes via redox relays and peroxiporins, shaping metabolism, unfolded-protein responses and cell-death thresholds, at mitochondrialysosome and peroxisomemitochondria interfaces, fatty-acid flux, the labile iron pool (LIP) and ROS/RSS hand-offs are co-regulatedperoxisomal -oxidation and catalase buffering, lysosomal iron mobilization and mitochondrial electron transport together set the likelihood of Fenton chemistry and lipid peroxidation (DiGiovanni et al
Diabetes 53:410417 Cryer PE (2012) Minireview: glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
In the era of personalized medicine, single-cell sequencing at genetic and epigenetic levels may contribute to a better understating of the pathogenicity of T2DM and its treatment
The medication delays gastric emptying, which can increase the risk of aspiration during anaesthesia
(2023) Association of glucagonlike peptide1 receptor agonist treatment with gastric residue in esophagogastroduodenoscopy
Fidgeting, standing, walking around the house, taking stairs instead of elevators, parking farther away
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