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Plasma obtained from healthy adults following a single 300 mg oral dose of PYC induced pronounced apoptotic cell death in human fibrosarcoma (HT1080) cells, whereas plasma from untreated individuals showed no such effect (Harati et al., 2015)

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A systematic review found hot flashes and night sweats were common during perimenopause, and a newer study found the rise in hot flushes was especially noticeable in late perimenopause