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The mechanism of an altered epigenetic control due to abnormal chromosomal and mitochondrial DNA methylation linked to the folate deficiency and hyperhomocysteinemia (Hhcy) is characteristic for several severe pathologies such as the leading cause of blindness in humans by proliferative diabetic retinopathy demonstrating a vicious circle in uncontrolled ROS production and irreversible damage to chromosomal and mitochondrial DNA [453]
Ieee Transactions on Biomedical Engineering , 65 (10), 22372247
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Given its effects on metabolism and gastrointestinal motility, there has been growing interest in the potential application of Semaglutide in treating conditions beyond diabetes and obesity, including IBS
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