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The goal is sustainable treatment that balances efficacy with tolerability, and multiple evidence-based options exist to support this

Since CPT I is the major player in mitochondrial transport and oxidation of LCFA, its inhibition by SUN could inhibit the translocation of LCFA from cytoplasmic compartment into mitochondrial compartment where -oxidation enzymes are located

Expect those results to be revealed soon

Common adverse effects include nausea, vomiting, diarrhoea, abdominal pain, and decreased appetite, particularly during dose escalation

Dose reduction to 1.7 mg maintenance or alternative GLP-1 receptor agonists may be considered if the 2.4 mg dose cannot be tolerated

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