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Interestingly, despite the lower measured AUC after nocturnal dosing, a recent study showed no significant reduction in pharmacodynamic effect (38)

Ethics statement The studies involving human participants were reviewed and approved by Ethics Committee of the Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University

Some researchers investigate topical delivery methods in relevant study contexts

Metabolics obesity drug - phase 2B clinical trial results: trial results do not support commercial viability of obesity project: programme is terminated [ASX Announcement]

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