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I expect you've already been reading about this, but if you want more information, there's lots on this site - just do a search for 'co-factors' and lots will pop up

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While some stress to necessary (cortisol spikes to get us up in the morning, for example), we can run into problems when the HPA axis is stimulated too much and too frequently

We might expect that even broader variety of resistance mechanisms would be revealed were it to be used in clinical settings

The alteration of chloride homeostasis/GABAergic signaling in brain disorders: could oxidative stress play a role