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Reduce to every-other-day dosing for one week, then stop entirely
, Phase 1 studies evaluated safety, tolerability, and pharmacokinetic characteristics Early data from Phase 2 investigations provided insights into biological activity and physiological responses
TNF- and MCP-1 expression was once again attenuated in human peripheral blood mononuclear cells
, providing oxaloacetate or boosting ETC flux) pushed macrophages towards an M2 profile (21)
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