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Due to limited market demand and its long growth cycle, durian remained in a state of being introduced but not evaluated or domesticated after its introduction

Commonly reported ones include gastrointestinal issues like nausea and diarrhea, typically present when starting or adjusting the dosage

doi: 10.2169/internalmedicine.1055-18

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"Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites" (PDF)