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While that might seem like retatrutide is a clear winner, its not the whole picture

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[DOI] [PubMed] [Google Scholar] 24.Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction

They also observed a drop in a key inflammatory biomarker

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This is higher than standard recommendations (0.8g/kg) because protein needs significantly increase during caloric restriction to prevent muscle breakdown and support muscle protein synthesis