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When folate cycling is impaired by MTHFR insufficiency, the dihydrofolate THF step accumulates dihydrofolate, competing with the BH2 BH4 reduction step for DHFR activity and NADPH

Another pilot study by Li et al

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We can make a joke about how incredibly stupid it all is, but its no joke that Kennedy has the potential to kill hundreds of thousands and upend or ruin millions of lives that have been made well by prescribed medication backed by decades of clinical research

I have done so and now snack on salads, not pizzas