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other components cleared more rapidly The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all four components and their potential interactions

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For meaningful scar improvement, in-clinic deeper needling produces more dramatic results

Despite the promising therapeutic potential of MSCs for PH, broader large-scale production and clinical application require addressing key challenges of MSCsincluding heterogeneity, tumorigenicity, reduced biological function, and senescence during in vitro culturethrough the following strategies: standardizing MSC preparation and enriching homogeneous subpopulations using flow cytometry and immunomagnetic bead sorting