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The estimate of liver necrosis is rather small, less that 0.05% damage, and this may be sufficient to account for the elevation of ALT observed by Watkins et al.[38], and the absence of symptoms of liver disease after chronic usage

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Keywords: drug utilization, epidemiology, anti-obesity drugs, glucose-lowering drugs, obesity, type 2 diabetes Introduction Worldwide the prevalence of obesity and type 2 diabetes (T2D) is high and rapidly increasing