In a prospective cohort study involving a clinical population of 1,228 women of childbearing age who were planning to conceive naturally, those who were exposed to SSRIs experienced a 24% reduction in the ability to conceive, with fluoxetine exerting an even more pronounced effect than other SSRIs, as well as a 9% reduction in the incidence of live births
For someone starting at 240 pounds, thats about 58 pounds
These risks are not being adequately communicated to patients, and shockingly, they are not listed in the official warning labels for most GLP-1 drugs
If side effects emerge during dose increases, clinicians may consider reverting to the previously well-tolerated dose and then gradually reintroducing titration, or alternatively, establishing a maximum tolerated dose for continued therapy
This results in production of ROS to levels that are sufficient to induce the MPT (76)
Parab & Doshi 2023)