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Researchers calibrated the CORE model with baseline characteristics from LEAD-1 and projected outcomes, including survival rates, cardiovascular, ophthalmic, and renal events incidence, and healthcare expenditures over 10-, 20-, and 30-year intervals (16)(17)

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Taniya De Silva, an endocrinologist at LSU Health New Orleans who frequently treats patients with diabetes and obesity

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The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

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