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This makes it relevant to laboratory investigations involving receptor cross-talk, metabolic adaptation, glucose-associated signaling, appetite-associated pathway biology, energy expenditure models, substrate utilization, hepatic metabolic signaling, and adipose-associated response systems

Its location near a fenestrated blood-brain barrier permits it to sense circulating hormones and nutrients, including insulin, gut hormones, leptin, serotonin, glucose, and free fatty acids [22, 23]

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