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In a larger Israel study of 100 type 2 diabetic patients (glycated HbAic 9.2%), TK activity was lower than the minimum normal range in 18% of diabetics

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These can include gastrointestinal issues, skin rashes, or allergic reactions in rare cases

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Finally, a large proportion of the other studies reviewed herein, including the ones focused on exercise, did not include or report on mitochondrial readouts following NAD + modulation