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For most users, these compounds require ongoing maintenance dosing at either the target dose or a reduced maintenance level

Higher circulating trimethylamine N-oxide aggravates cognitive impairment probably via downregulating hippocampal SIRT1 in vascular dementia rats

10.1016/s0928-4257(01)00036-5 118 SikiricP.SeiwerthS.GrabarevicZ.PetekM.RucmanR.TurkovicB.et al (1994)

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Although PDs etiology remains largely enigmatic, evidence implicates genetic mutations, environmental toxins, oxidative stress, mitochondrial impairment, and neuroinflammation in its pathogenesis (Madiha et al., 2021)