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ZincHomocysteine binding in cobalamin-dependent methionine synthase and its role in the substrate activation: DFT, ONIOM, and QM/MM molecular dynamics studies

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3 Results 3.1 Identification of DE-FRGs in the GSE73680 dataset 8 of 237 ferroptosis-related genes (FRGs) showed significant differential expression, with 4 genes upregulated and 4 genes downregulated in Randalls Plaque tissue from calcium stone formers compared to normal papillary tissue from control patients without kidney stones (Supplementary Table S2)