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Thus, blockade of hepatic portal GLP-1R signaling causes glucose intolerance in rats, suggesting that GLP-1Rs located on nerve terminals in the hepatic portal vein contribute to the incretin action of GLP-1 (Vahl et al., 2007)

Safety Profile: What Is Known and Unknown Short-term animal studies generally report favorable tolerability without significant organ toxicity

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Among all those who reported microdosing, almost 25% had been doing so for six months or longer