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Katherine Tuttle, professor of medicine at the University of Washington School of Medicine and executive director for Research Providence Inland Northwest Health in Spokane, Washington, emphasized that people with type 1 diabetes have an especially high risk of chronic kidney disease (CKD)

Together with other major risk factors, type 2 diabetes must be considered as an important cause of cardiovascular disease

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514 UPR signaling in neuroinflammation, oligodendrocyte survival, and demyelination in MS ER stress is widely observed in demyelinating lesions in MS, with elevated levels of markers such as CHOP, BiP, phosphorylated PERK, phosphorylated eIF2, and XBP-1 in microglia, oligodendrocytes (OLs), T cells, and astrocytes