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The top-scoring compounds were then synthesised as described in the Chemistry supplementary information

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In challenge infections using WT UTI89 and UTI89 hlyA strains in nave, resolved and sensitized mice, we observed that hlyA infection, which does not activate caspase-1-mediated pyroptotic cell death, showed significantly increased bacterial burdens in sensitized mice compared with WT mice, whereas no differences were observed in nave and resolved mice (Fig

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Transkriptomische Analyse, 4 192 Gene