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We recently repurposed sertraline, an antidepressant that efficiently crosses the BBB, as a specific SHMT1/2 inhibitor with robust anti-cancer properties, effectively targeting ser/gly-dependent cancers in vitro and in vivo [33,34,35]

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Among the most promising of these is Withania somnifera , a botanical more commonly known as Ashwagandha (Salve et al

The GLP-1R affinity of Semaglutide is 0.380.06 nM[1]

JAMA 310, 21912194

Lancet 402(10402):613626 Neeland IJ, Marso SP, Ayers CR et al (2021) Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial