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Rarely, complications such as infection or color changes in the skin may occur

56 These results highlight the possibility that genetic variation may have significant effects on susceptibility toward cancer

However, regular or high-dose NSAID use demands periodic kidney function monitoring via serum creatinine and glomerular filtration rate (eGFR) testing

For many people the pattern eases over the weeks that follow as the gut adapts and eating habits settle into a steadier rhythm, so the effect is often most pronounced early and around dose changes rather than constant

36 Generally, drugs with smaller molecular weights are considered to have more potential in this regard