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Complete 20 consecutive days, then observe a 46 month off-cycle before repeating (typically 2 cycles per year) [5]

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In the SURPASS-EARLY trial, nearly 800 adults diagnosed with type 2 diabetes within the past four years whose disease was not adequately controlled with metformin, diet and exercise were assigned to add either tirzepatide or other medications

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The article says probiotic-induced bloating may initially worsen the gastrointestinal side effects already coming from the medication, even though genuine drug interactions are described as rare

You might get headaches on Mounjaro, but its much less likely as only 1 in 20 people report headaches