The STEP programme showed a weight loss of up to 16.9% after one year of treatment with SEMA 2.4 mg, mainly at the expense of fat mass (difference versus placebo: fat mass 3.29%
Most patients need long-term treatment to maintain weight loss
Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T, Suda T, Matsuo K
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion
There are no recommended pharmacological therapies for control of pruritus in cirrhosis
Thyroid function monitoring may shift slightly during GLP-1 initiation due to weight loss effects, but levothyroxine dosing remains stable in most cases, with adjustments reserved for patients showing actual laboratory changes in TSH levels