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HCPs must be aware of the possibility of these rare side effects to act early and avoid the complications related to volume depletion, such as severe renal failure [62,63]

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The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function

however, the limited resolution of the EM data does not allow for a precise conclusion about the molecular details of the various conformations