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The tolerability question is not trivial

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In the T2D trial, WL was lower than in the obesity trial however the trial duration was shorter (36 weeks) [46]

GLP-1 Receptor Biology The GLP-1 receptor (GLP-1R) is a class B GPCR (G-protein coupled receptor) expressed in pancreatic -cells, the hypothalamus, brainstem, heart, kidney, gastrointestinal tract, and lungs

Some people notice subtle appetite changes within 24 to 72 hours of their first injection, but most do not experience significant immediate appetite suppression at the 0.25 mg starting dose