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Common Causes of B12 Deficiency There are many reasons for vitamin B12 deficiency

10.1186/s12974-020-01905-2 36 MalhotraA.GrunsteinR

Berenbaum, F., Bougault, C

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For example, certain probiotics (e.g., lactobacilli ) reportedly activate the NRF2 pathway via metabolic routes [148], while some pathogens (e.g., Salmonella , Helicobacter pylori ) activate NOX1, upregulate ROS, and induce inflammation [149]

However, the reverse interactionthe microbiota modulating nutrient bioavailability [e.g., gut bacteria synthesizing B-group vitamins (144) or converting inorganic selenium to organic selenocysteine (265)]has not been linked to depression