Chronic Stress : Long term physical or emotional stress increases oxidative stress, which can deplete the bodys natural antioxidant reserves
Patients with a personal or family history of breast cancer should use choline supplementation cautiously, as some observational studies suggest high-dose choline intake correlates with increased breast cancer risk in genetically susceptible populations
Ralli M, Angeletti D, Fiore M, DAguanno V, Lambiase A, Artico M, de Vincentiis M, Greco A
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256 Conclusion and Future Directions TMAO may drive the cross-talk between inflammatory response and oxidative stress by mediating cell death (including apoptosis, pyroptosis, autophagy, and ferroptosis, etc) and then induce pathological processes such as foam cell activation, massive secretion of cytokines and adhesion molecules, overaccumulation of ROS, enhanced platelet reactivity and abnormal vascular tone regulation
always work with your GP or endocrinologist