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We've learned that we start with the dose based upon these, like you said, animal studies, which is conservative, make sure it's safe

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Skin, hair, or metabolic goals: every 23 weeks

Preclinical data in glioblastomas showed that a single implant markedly reduced local recurrence and produced a median survival benefit, while pharmacokinetic studies showed therapeutic intraparenchymal temozolomide levels for over four weeks with minimal systemic exposure

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Nanoscale 8(47):1949119509 Hong Y, Zhao H, Pu C, Zhan Q, Sheng Q, Lan M (2018) Hydrophilic phytic acid-coated magnetic graphene for titanium (IV) immobilization as a novel hydrophilic interaction liquid chromatography-immobilized metal affinity chromatography platform for glyco- and phosphopeptide enrichment with controllable selectivity