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The major metabolite of saxagliptin is also a DPP-4 inhibitor, which is one-half as potent as saxagliptin

Further modifications to exenatide yielded lixisenatide (Lyxumia, Sanofi-Aventis), which has an extended C-terminus including six consecutive lysine residues

Routine ultrasound screening is not necessary for low-risk patients without symptoms or family history of thyroid cancer

In reality, many patients experience some degree of weight regain, and there can also be deterioration in cardiometabolic markers

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