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Providing a treatment option that is proven to lower this cardiovascular risk is a major advance for public health. Around 5.5% of American adults have cardiovascular disease and 70% of Americans are classified as having overweight or obesity, making this a treatment that can potentially impact a portion of the population

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Evening dosing optimizes both outcomes because MC4R (appetite regulation) and MC1R (pigmentation) receptor peaks both occur during late evening and overnight hours

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