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Conlon, M
Proc Natl Acad Sci USA 2002
CJC-1295 NO DAC functions through specific binding to growth hormone-releasing hormone receptors located in the anterior pituitary gland, leading to activation of adenylyl cyclase and increased cyclic adenosine monophosphate (cAMP) levels
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Previous studies identified an activating mutation within the ligand binding domain of NHR-49 at valine 411 where this hydrophobic valine was mutated to a charged glutamic acid 54,55
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