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p = 0.02) in this population

Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

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But this edge in effectiveness is only one of the differences between the two drugs

doi: 10.1016/S0140-6736(17)30069-7 91 KellerJTrautmannMEHaberHThamLSHuntTMaceKet al