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London: University College London

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Orthosteric binding of incretin peptides to the N-terminus (extracellular) region of the receptors causes a conformational change, stabilizing a binding site in the intracellular region that allows coupling to and activation of heterotrimeric guanine nucleotide-binding protein (G proteins) ( a and subunits to dissociate triggering different signalling cascades

G.HeiseT.Plum-MoerschelL.et al (2018)