Lancet 403, 283292
Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field
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LEfSe results showed enrichment of beneficial Lactobacillus taxa and suppression of potential pathogens (e.g., Streptococcus, Pasteurellaceae, Terrisporobacter ) in controls
Inhibition of GR prevents Bd from converting GSSG into GSH, and from our previous studies on GSH depletion, we predicted that 2-AAPA would have some impacts on growth and metal tolerance (27)
