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With doses of 10 nmol/kg and higher, rats exhibited not only a lack of activity, but also notable changes in facial expressions associated with pain and nausea including orbital tightening and nose/cheek flattening compared to rats treated with vehicle alone

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Protocol 2: CJC-1295 With DAC Plus Ipamorelin CJC-1295 with DAC: 1,000-2,000 mcg subcutaneous injection once weekly Ipamorelin: 200-300 mcg subcutaneous injection, 2x daily Cycle length: 12-16 weeks Monitoring: Fasting IGF-1 at baseline and at 8 weeks