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Notably, -catenin silencing abolishes the protective effects of Vitamin D, leading to increased ROS levels, impaired migration, and elevated apoptosis, indicating that -catenin activation is indispensable for Vitamin Dmediated cytoprotection

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PMID: 41090431 | doi:10.1111/dom.70209 Katsi V et al

A 42-year-old female with longstanding profound fatigue, chronic pain, asthma, multiple food intolerances, GI symptoms including diarrhea, urticaria, food cravings, weight gain, and migraine who was essentially housebound due to constant exhaustion (she estimated 30% of normal energy) took tirzepitide at 3.75 mg principally to address obesity

Some users find their heartburn is better at month 6 than it was before starting the medication, because the weight loss benefit outweighs the gastric slowing effect